{"id":42445,"date":"2025-05-20T09:06:53","date_gmt":"2025-05-20T09:06:53","guid":{"rendered":"https:\/\/naturaleyecare.com\/?post_type=vision&#038;p=42445"},"modified":"2025-11-06T08:35:28","modified_gmt":"2025-11-06T08:35:28","slug":"bests-disease","status":"publish","type":"vision","link":"https:\/\/naturaleyecare.com\/eye-conditions\/bests-disease\/","title":{"rendered":"Best&#8217;s Disease"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"42445\" class=\"elementor elementor-42445\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4984a1d e-con-full e-flex cmsmasters-block-default e-con e-parent\" data-id=\"4984a1d\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-a3a9d6e e-con-full e-flex cmsmasters-block-default e-con e-child\" data-id=\"a3a9d6e\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-fa6dd2f cmsmasters-block-default cmsmasters-sticky-default elementor-widget elementor-widget-text-editor\" data-id=\"fa6dd2f\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/naturaleyecare.com\/ocular-support\/retinal-support\/\">Vitamins\/supplements for retinal support<\/a><\/p><p>Best&#8217;s disease, also known as Best&#8217;s vitelliform macular dystrophy, is a hereditary (usually) form of progressive macular dystrophy.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c1b9b09 e-con-full e-flex cmsmasters-block-default e-con e-parent\" data-id=\"c1b9b09\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-25f14df e-n-tabs-mobile cmsmasters-block-default cmsmasters-sticky-default elementor-widget elementor-widget-n-tabs\" data-id=\"25f14df\" data-element_type=\"widget\" data-settings=\"{&quot;tabs_justify_horizontal&quot;:&quot;start&quot;,&quot;horizontal_scroll&quot;:&quot;disable&quot;}\" data-widget_type=\"nested-tabs.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"e-n-tabs\" data-widget-number=\"39785695\" aria-label=\"Tabs. Open items with Enter or Space, close with Escape and navigate using the Arrow keys.\">\n\t\t\t<div class=\"e-n-tabs-heading\" role=\"tablist\">\n\t\t\t\t\t<button id=\"e-n-tab-title-397856951\" data-tab-title-id=\"e-n-tab-title-397856951\" class=\"e-n-tab-title\" aria-selected=\"true\" data-tab-index=\"1\" role=\"tab\" tabindex=\"0\" aria-controls=\"e-n-tab-content-397856951\" style=\"--n-tabs-title-order: 1;\">\n\t\t\t\t\t\t<span class=\"e-n-tab-title-text\">\n\t\t\t\tStages \t\t\t<\/span>\n\t\t<\/button>\n\t\t\t\t<button id=\"e-n-tab-title-397856952\" data-tab-title-id=\"e-n-tab-title-397856952\" class=\"e-n-tab-title\" aria-selected=\"false\" data-tab-index=\"2\" role=\"tab\" tabindex=\"-1\" aria-controls=\"e-n-tab-content-397856952\" style=\"--n-tabs-title-order: 2;\">\n\t\t\t\t\t\t<span class=\"e-n-tab-title-text\">\n\t\t\t\tSymptoms\t\t\t<\/span>\n\t\t<\/button>\n\t\t\t\t<button id=\"e-n-tab-title-397856953\" data-tab-title-id=\"e-n-tab-title-397856953\" class=\"e-n-tab-title\" aria-selected=\"false\" data-tab-index=\"3\" role=\"tab\" tabindex=\"-1\" aria-controls=\"e-n-tab-content-397856953\" style=\"--n-tabs-title-order: 3;\">\n\t\t\t\t\t\t<span class=\"e-n-tab-title-text\">\n\t\t\t\tCauses\t\t\t<\/span>\n\t\t<\/button>\n\t\t\t\t<button id=\"e-n-tab-title-397856954\" data-tab-title-id=\"e-n-tab-title-397856954\" class=\"e-n-tab-title\" aria-selected=\"false\" data-tab-index=\"4\" role=\"tab\" tabindex=\"-1\" aria-controls=\"e-n-tab-content-397856954\" style=\"--n-tabs-title-order: 4;\">\n\t\t\t\t\t\t<span class=\"e-n-tab-title-text\">\n\t\t\t\tTreatment\t\t\t<\/span>\n\t\t<\/button>\n\t\t\t\t<button id=\"e-n-tab-title-397856955\" data-tab-title-id=\"e-n-tab-title-397856955\" class=\"e-n-tab-title\" aria-selected=\"false\" data-tab-index=\"5\" role=\"tab\" tabindex=\"-1\" aria-controls=\"e-n-tab-content-397856955\" style=\"--n-tabs-title-order: 5;\">\n\t\t\t\t\t\t<span class=\"e-n-tab-title-text\">\n\t\t\t\tNews\t\t\t<\/span>\n\t\t<\/button>\n\t\t\t\t\t<\/div>\n\t\t\t<div class=\"e-n-tabs-content\">\n\t\t\t\t<div id=\"e-n-tab-content-397856951\" role=\"tabpanel\" aria-labelledby=\"e-n-tab-title-397856951\" data-tab-index=\"1\" style=\"--n-tabs-title-order: 1;\" class=\"e-active elementor-element elementor-element-3b64840 e-con-full e-flex cmsmasters-block-default e-con e-child\" data-id=\"3b64840\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-6ba1fce e-con-full e-flex cmsmasters-block-default e-con e-child\" data-id=\"6ba1fce\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-bfbeabc cmsmasters-block-default cmsmasters-sticky-default elementor-widget elementor-widget-image\" data-id=\"bfbeabc\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"475\" height=\"326\" src=\"https:\/\/naturaleyecare.com\/wp-content\/uploads\/2025\/05\/bests-x-section-1-1.webp\" class=\"attachment-large size-large wp-image-61390\" alt=\"bests-x-section-1-1\" srcset=\"https:\/\/naturaleyecare.com\/wp-content\/uploads\/2025\/05\/bests-x-section-1-1.webp 475w, https:\/\/naturaleyecare.com\/wp-content\/uploads\/2025\/05\/bests-x-section-1-1-300x206.webp 300w, https:\/\/naturaleyecare.com\/wp-content\/uploads\/2025\/05\/bests-x-section-1-1-437x300.webp 437w\" sizes=\"(max-width: 475px) 100vw, 475px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-579a440 cmsmasters-block-default cmsmasters-sticky-default elementor-widget elementor-widget-text-editor\" data-id=\"579a440\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tThe condition can be identified between 3 and 15 years of age.\n\nThere are five stages to this disease as follows:\n<ol style=\"list-style-type: none;\">\n \t<li>Pre vitelliform: Initially a recording of eye movements and eye position identifies abnormal electrical potential. Eyes will be tested resting or moving in dark and light conditions.<\/li>\n \t<li>Vitelliform: Usually occurs between 10-25 years of age. Typical yellow spots, sometimes accompanied by material leaking into a space by the retina can be observed; an observation called &#8220;egg-yolk&#8221; lesion.<\/li>\n \t<li>Pseudohypopyon: When part of the lesion becomes absorbed, this is identified as stage three. Even at this stage there may be little effect on vision.<\/li>\n \t<li>Vitelliruptive: At this stage, when the &#8220;egg-yolk&#8221; breaks up in a process referred to as &#8220;scrambled-egg&#8221;, sight will probably be affected.<\/li>\n \t<li>Atrophic: The fifth and final stage is when the condition causes the most severe sight loss.<\/li>\n \t<li>Plus a Complication:\u00a0<a href=\"https:\/\/naturaleyecare.com\/eye-conditions\/choroidal-neovascularization\/\">Choroidal neovascularization<\/a>\u00a0results in about 1 in 5 patients.<\/li>\n<\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cf6de19 cmsmasters-block-default cmsmasters-sticky-default elementor-widget elementor-widget-text-editor\" data-id=\"cf6de19\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h4>Stages<\/h4>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div id=\"e-n-tab-content-397856952\" role=\"tabpanel\" aria-labelledby=\"e-n-tab-title-397856952\" data-tab-index=\"2\" style=\"--n-tabs-title-order: 2;\" class=\" elementor-element elementor-element-f1a4fb9 e-con-full e-flex cmsmasters-block-default e-con e-child\" data-id=\"f1a4fb9\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-6654d78 e-con-full e-flex cmsmasters-block-default e-con e-child\" data-id=\"6654d78\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7b90e5d cmsmasters-block-default cmsmasters-sticky-default elementor-widget elementor-widget-text-editor\" data-id=\"7b90e5d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h4 id=\"symptoms\">Symptoms <\/h4>\nGradual loss of central vision.\n\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div id=\"e-n-tab-content-397856953\" role=\"tabpanel\" aria-labelledby=\"e-n-tab-title-397856953\" data-tab-index=\"3\" style=\"--n-tabs-title-order: 3;\" class=\" elementor-element elementor-element-05bff03 e-con-full e-flex cmsmasters-block-default e-con e-child\" data-id=\"05bff03\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-808f65f e-con-full e-flex cmsmasters-block-default e-con e-child\" data-id=\"808f65f\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-143de52 cmsmasters-block-default cmsmasters-sticky-default elementor-widget elementor-widget-text-editor\" data-id=\"143de52\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h4 id=\"causes\">Causes<\/h4><p>Best&#8217;s vitelliform macular dystrophy is a condition that tends to run genetically in families due to a mutation in the VMD2 gene. The mutation can be transmitted by only one parent. Without any family history of Best&#8217;s disease, about 25% of Best&#8217;s patients will also have this genetic mutation. Researchers have found over 40 mutation variations in this gene. The researchers also concluded that a few patients who are diagnosed as having macular degeneration (AMD) actually have late onset Best&#8217;s.<sup>1<\/sup><\/p><p>The VMD2 gene encodes bestrophin, a protein form which is found in a wide variety of organisms where it is thought move chloride atoms around in the retinal cells. This process regulates pH levels, movement of solutes among cells, cell growth and cell movement. Mutations in the VMD2 gene, causing malfunctioning of bestrophin permits fatty yellow pigments to build up in the cells between the macula<\/p><p>The related vitelliform macular dystrophy is caused by mutations of either the same VMD2 gene or the RDS.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div id=\"e-n-tab-content-397856954\" role=\"tabpanel\" aria-labelledby=\"e-n-tab-title-397856954\" data-tab-index=\"4\" style=\"--n-tabs-title-order: 4;\" class=\" elementor-element elementor-element-4b27abb e-con-full e-flex cmsmasters-block-default e-con e-child\" data-id=\"4b27abb\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-894a07a e-con-full e-flex cmsmasters-block-default e-con e-child\" data-id=\"894a07a\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-15c0cba cmsmasters-block-default cmsmasters-sticky-default elementor-widget elementor-widget-text-editor\" data-id=\"15c0cba\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h4>Conventional Treatment<\/h4><p>There has been no conventional treatment, although the literature has a reference to one patient injected with bevacizumab.<sup>2<\/sup>\u00a0A 2015 report of photodynamic therapy shows some promise. Photodynamic therapy (PDT) involves using a light-sensitive drug, which, when exposed to specific light wavelengths create a oxygen type that kills adjacent cells. The researchers evaluated 30 patients, three of whom had received PDT treatment. There was an average 77 month followup during which there was stable vision functioning followed by slowly improving vision functioning for several years.<sup>3<\/sup>\u00a0This study substantiated a 2003 report involving a single patient.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div id=\"e-n-tab-content-397856955\" role=\"tabpanel\" aria-labelledby=\"e-n-tab-title-397856955\" data-tab-index=\"5\" style=\"--n-tabs-title-order: 5;\" class=\" elementor-element elementor-element-ba92928 e-con-full e-flex cmsmasters-block-default e-con e-child\" data-id=\"ba92928\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-f476b5c e-con-full e-flex cmsmasters-block-default e-con e-child\" data-id=\"f476b5c\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b2a515f cmsmasters-block-default cmsmasters-sticky-default elementor-widget elementor-widget-text-editor\" data-id=\"b2a515f\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h4 id=\"treatment\">Self Help<\/h4><p>Lifestyle choices and diet can play a major factor in helping manage Best&#8217;s disease. See our homeopathic products and recommendations for supporting the macula in the sidebar.<\/p><p>Certain nutrients such as\u00a0<a href=\"https:\/\/naturaleyecare.com\/nutrients\/carotenoids\/lutein\/\" target=\"_blank\" rel=\"noopener\">lutein<\/a>,\u00a0<a href=\"https:\/\/naturaleyecare.com\/nutrients\/carotenoids\/zeaxanthin\" target=\"_blank\" rel=\"noopener\">zeaxanthin<\/a>, vinpocetine, l-lysine, a number of vitamins &amp; enzymes, and fish oil may help slow down Best&#8217;s Disease and preserve vision.<\/p><p>Daily juicing of vegetables and fruits (preferably organic). Our suggested retinal support recipe is a combination of some the following: ginger, garlic, leeks, parsley, beets, cabbage, carrots, celery, spinach, apples, grapes, raspberries, lemon, chlorophyll, wheat grasses (not too much fruit). See\u00a0<a href=\"https:\/\/naturaleyecare.com\/eye-disease-prevention\/juicing-food-for-your-eyes\/\">more juicing information<\/a>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e2d3e3a e-con-full e-flex cmsmasters-block-default e-con e-parent\" data-id=\"e2d3e3a\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-bfcb905 cmsmasters-block-default cmsmasters-sticky-default elementor-widget elementor-widget-heading\" data-id=\"bfcb905\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Best's Disease News<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f5526e7 cmsmasters-block-default cmsmasters-sticky-default elementor-widget elementor-widget-text-editor\" data-id=\"f5526e7\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Want to learn more? See our blog news on Best&#8217;s disease.<\/p>\n\n<p><img decoding=\"async\" class=\"pointer\" src=\"https:\/\/naturaleyecare.com\/wp-content\/uploads\/2025\/05\/menu-terms-1.jpg\" alt=\"\" \/>\u00a0<a href=\"https:\/\/naturaleyecare.com\/ocular-support\/retinal-support\/\">Find Vitamins &amp; Supplements to Support the Retina<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6dac0f9 e-con-full e-flex cmsmasters-block-default e-con e-parent\" data-id=\"6dac0f9\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-cbdf2e8 cmsmasters-block-default cmsmasters-sticky-default elementor-widget elementor-widget-heading\" data-id=\"cbdf2e8\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Research<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-79380fb cmsmasters-block-default cmsmasters-sticky-default elementor-widget elementor-widget-text-editor\" data-id=\"79380fb\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Although the underlying physiological cause may be unique, there may be similarities in terms of nutritional, diet and lifestyle recommendations made by Dr. Grossman for eye conditions that result in similar vision symptoms to those of Best&#8217;s Disease.<\/p><p><b>Footnotes<\/b><\/p><p class=\"small\"><em>1. Andrew J. Lotery, et al, Allelic Variation in the VMD2 Gene in Best Disease and Age-Related Macular Degeneration, Biochemistry and Molecular Biology, May, 2000.<\/em><br \/><em>2. C. Celea, et al, Evolution of Choroidal Neovascular Membrane in Best Disease after Single Intravitreal Bevacizumab. Case Report, Maedica, March, 2015.<\/em><br \/><em>3. A. Sodi, et al, Long-Term Results of Photodynamic Therapy for Choroidal Neovascularization in Pediatric Patients with Best Vitelliform Macular Dystrophy, Ophthalmic Genetics, June, 2015.<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Vitamins\/supplements for retinal support Best&#8217;s disease, also known as Best&#8217;s vitelliform macular dystrophy, is a hereditary (usually) form of progressive macular dystrophy. Stages Symptoms Causes Treatment News The condition can be identified between 3 and 15 years of age. There are five stages to this disease as follows: Pre vitelliform: Initially a recording of eye&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-42445","vision","type-vision","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.8 (Yoast SEO v26.8) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Best&#039;s Disease News, Symptoms &amp; Treatment<\/title>\n<meta name=\"description\" content=\"Vitelliform macular dystrophy, or egg-yolk lesion are alternative names for Best&#039;s Disease. 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